![]() Detection of viable Mycobacterium avium subspecies Paratuberculosis in powdered infant formula by phage-PCR and confirmed by culture. doi:10.1155/2012/785262.īotsaris G, Swift B.M.C, Slana I, Liapi M, Christodoulou M, Hatzitofi M, Christodoulou V, Rees C.E. paratuberculosis in an Italian Cohort of Type 1 Diabetes Pediatric Patients. doi:10.1186/1297-.īitti M.L.M, Masala S, Capasso F, Rapini N, Piccinini S, Angelini F, Pierantozzi A, Lidano R, Pietrosanti S, Paccagnini D, Sechi L.A. From mouth to macrophage:mechanisms of innate immune subversion by Mycobacterium avium subsp. doi:10.1186/s1309-3.Īrsenault R.J, Maattanen P, Daigle J, Potter A, Griebel P, Napper S. RHB-104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn's disease associated with Mycobacterium paratuberculosis. ![]() Detection of Mycobacterium avium subspecies paratuberculosis in powdered infant formula using IS900 quantitative PCR and liquid culture media. The possibility of zoonotic transmission of the organism and its significant risk to public health safety as a consequence is also discussed.Īuto-immune Human morbidity Mycobacterium paratuberculosis Public health Zoonotic.Īcharya K.R, Dhand N.K, Whittington R, Plain K.M. Here, the author presents current information assessing the link between numerous diseases states in humans such inflammatory bowel disease, Type 1 diabetes, rheumatoid arthritis, Hashimoto\'s thyroiditis, multiple sclerosis and autism following infection with Mycobacterium avium paratuberculosis. Theoretically, this failure to recognise the invading organism as distinct from host cells may result in numerous autoimmune conditions. Following colonisation of the host, the parasitic organism evades the host immune system by use of molecular mimicry, displaying peptide sequences similar to that of the host cells causing a disruption of self-verses non self-recognition. Mycobacterium avium may be spread from animal to human hosts by water and foodborne transmission routes, where the foodborne route of exposure represents a significant risk for susceptible populations, namely children and the immune-compromised. The link between infection with this pathogen and human disease has been theorised for many years with Crohn's disease being one of many suspected resultant conditions. ![]() Infection with this microorganism results in substantial farming economic losses and animal morbidity. Mycobacterium avium subspecies paratuberculosis is a bacterial parasite and the causative agent of paratuberculosis, a disease predominately found in cattle and sheep. ![]()
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